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Bone graft substitutes for segmental defects in long bones

Developing 3D printed synthetic bone grafts with antibiotics to treat large bone defects and prevent infection.

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Bone graft substitutes for segmental defects in long bones

The autograft needs to be replaced with a synthetic bone graft that may contain BMPs (bone morphogenic proteins), stem cells, and antibiotics to treat the large bone defect and prevent infection.

Objectives of the project

  1. Development of a novel biomimicking composite formulation for 3D printing of bone graft substitute.
  2. Devising a strategy to encapsulate the gentamycin antibiotic.
  3. Collection of patient CT data and generation of CAD model of the defect site and 3D printing of bone graft.
  4. In vitro and in vivo evaluation of the generated bone graft substitute.

Timeline and Budget

  • Year 1: 10 Lakhs
  • Year 2: 10 Lakhs
  • Year 3: 10 Lakhs

Proposer: Dr. Falguni Pati, Associate Professor, Department of Biomedical Engineering